Is réamhchéim é an ranníocaíocht seo chun staidéar a dhéanamh ar phróitéiní i samplaí othar chun a carnadh a chosc agus mar sin comharthaí gaolmhara. Fuarthas na sonraí turgnamhacha ó mhúnla ainmhithe luch a chruthaigh na taighdeoirí, a atáirgeann carnadh blúirí próitéine le linn an ghalair.
Sa saothar foilsithe, dhírigh na taighdeoirí ar an blúire de neurexin próitéin synaptic, ar a dtugtar nrxnctf sa phobal eolaíoch. Carnann an blúire seo i gcás sóchán sa ghéin presilin a chruthaíonn galar Alzheimer teaghlaigh. Thug na taighdeoirí faoi deara go bhféadfadh lochtanna cuimhne sonracha a bheith mar thoradh ar a carnadh turgnamhach san inchinn de shamhlacha ainmhithe. Tá samhlacha turgnamhacha de na galair seo an-tábhachtach chun an pathogenesis a chinneadh agus bunús teiripe éifeachtach a dhearadh.
The researchers observed in behavioral studies that the accumulation of this protein leads to the loss of associative memory dependent on the brain39;s amygdala. In collaboration with Jos é Mar í a Delgado of the University of Pablo de oravide, synaptic connections from the prefrontal cortex to the amygdala were studied using electrophysiological records in mice. These experiments show that the accumulation of nrxnctf can also produce presynaptic plasticity defects.
Neurexin
Neurexin is a transmembrane protein expressed in neurons and (neuroendocrine) cells. Neurexin exists in a variety of subtypes because they are encrypted by three genes, which are transcribed by two promoters and further modified by extensive alternative splicing. － Neurexin and － Neurexin protein consists of ligand binding domains that bind to several extracellular and intracellular interaction partners. Mouse genetics has proved － Neurexins play an important role in Ca2 plus reduce dependent synaptic transmission and a secondary role in synaptic formation. conversely, － Neurexins showed a strong potential to induce and differentiate synapses in cell culture experiments. Therefore, neurexin has become a key synaptic cell adhesion molecule and plays an important role in Ca2 plus reduce triggered release and synaptic development.
